Studying the right transporter at the right time: an <i>in vitro</i> strategy for assessing drug-drug interaction risk during drug discovery and development
Robert Elsby, Hayley Atkinson, Philip Butler, Robert J. Riley
Abstract
INTRODUCTION: data is critical to understanding risk. AREA COVERED: study design evaluating drugs as inhibitors or substrates. Guidance on identifying critical co-medications, clinically relevant disposition pathways, and using mechanistic static equations for quantitative prediction of DDI is compiled. EXPERT OPINION: DDI prediction, thereby contextualizing risk to ascertain whether a transporter DDI is simply pharmacokinetic or clinically significant requiring intervention.
Topics & Concepts
DrugTransporterDrug-drug interactionPharmacologyDrug developmentDrug discoveryMedicineComputational biologyBioinformaticsBiologyGeneBiochemistryDrug Transport and Resistance MechanismsPharmacological Effects and Toxicity StudiesPharmacogenetics and Drug Metabolism