Adaptive and Mutational Responses to Peptide Dendrimer Antimicrobials in Pseudomonas aeruginosa
Fatma Ben Jeddou, Léna Falconnet, Alexandre Lüscher, Thissa N. Siriwardena, Jean‐Louis Reymond, Christian van Delden, Thilo Köhler
Abstract
mutant background but not in the PA14 wild type. This suggests that both addition of 4-amino-l-arabinose and secretion of polyamines are required to reduce susceptibility to dendrimers, probably neutralizing the negative charges present on the lipid A and the 2-keto-3-deoxyoctulosonic acid (KDO) sugars of the lipopolysaccharide (LPS), respectively. We further show by transcriptome analysis that the dendrimers G3KL and T7 induce adaptive responses through the CprRS two-component system in PA14.
Topics & Concepts
OperonMutantPolymyxin BBiologyMicrobiologyBiochemistryLipid APseudomonas aeruginosaMolecular biologyChemistryAntibioticsGeneBacteriaGeneticsAntimicrobial Peptides and ActivitiesAntibiotic Resistance in BacteriaBacteriophages and microbial interactions