Targeting mTOR and eIF4E: a feasible scenario in ovarian cancer therapy
Alice Romagnoli, Cristina Maracci, Mattia D’Agostino, Anna La Teana, Daniele Di Marino
Abstract
. This minireview explores the possibility of targeting mTOR and eIF4E proteins, thus impacting on translation initiation in ovarian cancer, describing the most promising experimental strategies and specific inhibitors that have been shown to have an effect on other kinds of cancers.
Topics & Concepts
EIF4EPI3K/AKT/mTOR pathwayOvarian cancerCancer researchEffectorTranslation (biology)BiologyCancerSignal transductionTargeted therapyMessenger RNACell biologyGeneGeneticsPI3K/AKT/mTOR signaling in cancerPolyamine Metabolism and ApplicationsBiochemical and Molecular Research