ROS-responsive curcumin-encapsulated nanoparticles for AKI therapy <i>via</i> promoting lipid degradation in renal tubules
Honglei Guo, Tianyu Lan, Xin Lu, Kedui Geng, Xiangchun Shen, Huijuan Mao, Qianqian Guo
Abstract
A drug delivery system (NPS BG @Cur) has been developed to respond to ROS and deliver the autophagy activator curcumin (Cur) to reduce the severity of AKI. This system works by activating autophagy and promoting the degradation of lipid droplets.
Topics & Concepts
CurcuminAutophagyDegradation (telecommunications)Drug deliveryActivator (genetics)NanoparticleLipid dropletMaterials scienceNanotechnologyChemistryBiophysicsCell biologyPharmacologyMedicineBiochemistryApoptosisBiologyComputer scienceReceptorTelecommunicationsCannabis and Cannabinoid ResearchBiomedical Research and PathophysiologyAutophagy in Disease and Therapy