Synthesis of no-carrier-added [188, 189, 191Pt]cisplatin from a cyclotron produced 188, 189, 191PtCl42− complex
Honoka Obata, Katsuyuki Minegishi, Kotaro Nagatsu, Mikako Ogawa, Ming‐Rong Zhang
Abstract
Abstract We developed a novel method for production of no-carrier-added (n.c.a.) [ 188, 189, 191 Pt]Pt II Cl 4 2− from an Ir target material, and then synthesized n.c.a. [*Pt]cis-[Pt II Cl 2 (NH 3 ) 2 ] ([*Pt]cisplatin) from [*Pt]Pt II Cl 4 2− . [*Pt]Pt II Cl 4 2− was prepared as a synthetic precursor of n.c.a. *Pt complex by a combination of resin extraction and anion-exchange chromatography after the selective reduction of Ir IV Cl 6 2− with ascorbic acid. The ligand-substitution reaction of Cl with NH 3 was promoted by treating n.c.a. [*Pt]Pt II Cl 4 2− with excess NH 3 and heating the reaction mixture, and n.c.a. [*Pt]cisplatin was successfully produced without employing precipitation routes. After this treatment, [*Pt]cisplatin was isolated through preparative HPLC with a radiochemical purity of 99 + % at the end of synthesis (EOS).