Photocatalyzed Acylmethylation/Cyclization of Unactivated Alkenes with Sulfoxonium Ylides towards Acylmethylated Polycyclic Quinazolinones
Yechun Wu, Lingli Liu, Jin‐Tao Yu, Jin‐Tao Yu, Changduo Pan
Abstract
Abstract The synthesis of acylmethylatated pyrrolo‐quinazolinones was developed via photo‐induced cascade radical addition/cyclization of N ‐(but‐3‐enyl)quinazolin‐4(3 H )‐ones with sulfoxonium ylides using 4CzIPN as the photocatalyst. This approach was also suitable for the construction of acylmethylatated piperidino‐quinazolinones. This protocol features with mild conditions, convenient operation, broad substrate scope and good functional group compatibility.
Topics & Concepts
ChemistryCombinatorial chemistryOrganic chemistryQuinazolinone synthesis and applicationsCatalytic C–H Functionalization MethodsAdvanced Synthetic Organic Chemistry