Synthesis and Characterization of NUC-7738, an Aryloxy Phosphoramidate of 3′-Deoxyadenosine, as a Potential Anticancer Agent
Michaela Serpi, Valentina Ferrari, Christopher McGuigan, Essam Ghazaly, Chris Pepper
Abstract
potency. NUC-7738 is now in Phase II, dose-escalation study in patients with advanced solid tumors.
Topics & Concepts
PhosphoramidateChemistryDeoxyadenosineProdrugIn vitroAdenosine deaminaseNucleosideCordycepinBiochemistryPharmacologyIntracellularAdenosineBiologyBiochemical and Molecular ResearchAdenosine and Purinergic SignalingChronic Lymphocytic Leukemia Research