T cells, B cells, and PD-L1 expression in esophageal and gastric adenocarcinoma before and after neoadjuvant chemotherapy: relationship with histopathological response and survival
Maria Svensson, Albin Lindén, Jakob Nygaard, David Borg, Charlotta Hedner, Björn Nodin, Karin Leandersson, Karin Jirström
Abstract
density was an unfavorable prognostic factor, and high PD-L1 expression on TC was associated with a shorter survival. There were no significant associations between IC density or PD-L1 expression in PT pre-NAC and histopathological regression. These findings propose that NAC might alter the density and prognostic impact of some IC subsets in EG adenocarcinoma.
Topics & Concepts
FOXP3MedicineCD8AdenocarcinomaChemotherapyCD20ImmunohistochemistryContext (archaeology)OncologyNeoadjuvant therapyCancer researchInternal medicineImmune systemPathologyCancerImmunologyBiologyBreast cancerPaleontologyCancer Immunotherapy and BiomarkersGastric Cancer Management and OutcomesEsophageal Cancer Research and Treatment