Charge-based drug delivery to cartilage: Hydrophobic and not electrostatic interactions are the dominant cause of competitive binding of cationic carriers in synovial fluid
Armin Vedadghavami, Tengfei He, Chenzhen Zhang, Salima M. Amiji, Bill Hakim, Ambika G. Bajpayee
Topics & Concepts
Cationic polymerizationCartilageBiophysicsSynovial fluidHyaluronic acidOsteoarthritisSynovial jointStatic electricityHydrophobic effectDrug carrierChemistryMaterials scienceDrug deliveryIn vivoNanotechnologyBiochemistryOrganic chemistryArticular cartilageMedicineBiologyAnatomyEngineeringAlternative medicinePathologyElectrical engineeringBiotechnologyOsteoarthritis Treatment and MechanismsInflammatory mediators and NSAID effectsAntimicrobial Peptides and Activities