Withaferin A Protects against Primary and Recurrent Tuberculosis by Modulating Mycobacterium-Specific Host Immune Responses
Anjna Kumari, Isha Pahuja, Kriti Negi, Antara Ghoshal, Suparba Mukopadhyay, Meetu Agarwal, Babu Mathew, Jaswinder Singh Maras, Shivam Chaturvedi, Ashima Bhaskar, Ved Prakash Dwivedi
Abstract
Despite being extensive, conventional antituberculosis therapy (ATT) is barely proficient in providing sterile immunity to tuberculosis (TB). Failure to constrain the escalating global TB burden due to the emergence of drug-resistant bacterial strains and immune dampening effects of ATT necessitates adjunct immunotherapeutics for better clinical outcomes.
Topics & Concepts
Mycobacterium tuberculosisTuberculosisImmune systemImmunologyImmunityIsoniazidBiologyMedicinePathologyPhytochemicals and Medicinal PlantsTuberculosis Research and EpidemiologyAndrographolide Research and Applications