Where Does N-Formylmethionine Come from? What for? Where Is It Going?
Chang‐Seok Lee, Dasom Kim, Cheol‐Sang Hwang
Abstract
Different roles of N-formylmethionine (fMet) in different species and organelles. fMet was initially found in the translation process of bacteria, chloroplast, and mitochondria. Moreover, fMet promotes protein complex formation in mitochondria and works as a degradation signal in bacteria and yeast. Although the role of fMet in humans remains unresolved, a positive correlation between fMet, integrated stress response, and late-onset diseases has been identified. These unexpected results will guide further functional analysis of fMet in humans.
Topics & Concepts
OrganelleMitochondrionCell biologyYeastEukaryotic cellBiologyChemistryBiochemistryCellSulfur Compounds in BiologyFolate and B Vitamins ResearchEndoplasmic Reticulum Stress and Disease