Discovery of pyrazolo[3,4-<i>d</i>]pyrimidine and pyrazolo[4,3-<i>e</i>][1,2,4]triazolo[1,5-<i>c</i>]pyrimidine derivatives as novel CDK2 inhibitors: synthesis, biological and molecular modeling investigations
Ibrahim F. Nassar, Mohammed Taha Abdel Aal, Wael A. El‐Sayed, Mahmoud Ahmed Shahin, Elsayed G.E. Elsakka, Mahmoud Mohamed Mokhtar, Maghawry Hegazy, Mohamed Hagras, Asmaa A. Mandour, Nasser S. M. Ismail
Abstract
ADMET studies and drug-likeness studies using a Boiled Egg chart showed suitable pharmacokinetic properties which helped in structure requirement prediction for the observed antitumor activity.
Topics & Concepts
PyrimidineChemistryCombinatorial chemistryStereochemistrySynthesis and Characterization of Heterocyclic CompoundsQuinazolinone synthesis and applicationsSynthesis and biological activity