A general 11C-labeling approach enabled by fluoride-mediated desilylation of organosilanes
Wenchao Qü, Bao Hu, John W. Babich, Nicole N. Waterhouse, Marybeth Dooley, Shashikanth Ponnala, Julie Urgiles
Abstract
Abstract Carbon-11 ( 11 C) is one of the most ideal positron emitters for labeling bioactive molecules for molecular imaging studies. The lack of convenient and fast incorporation methods to introduce 11 C into organic molecules often hampers the use of this radioisotope. Here, a fluoride-mediated desilylation (FMDS) 11 C-labeling approach is reported. This method relies on thermodynamically favored Si-F bond formation to generate a carbanion, therefore enabling the highly efficient and speedy incorporation of [ 11 C]CO 2 and [ 11 C]CH 3 I into molecules with diversified structures. It provides facile and rapid access to 11 C-labeled compounds with carbon-11 attached at various hybridized carbons as well as oxygen, sulfur and nitrogen atoms with broad functional group tolerance. The exemplified syntheses of several biologically and clinically important radiotracers illustrates the potentials of this methodology.