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Central Mechanisms of Acetaminophen Hepatotoxicity: Mitochondrial Dysfunction by Protein Adducts and Oxidant Stress

Hartmut Jaeschke, Anup Ramachandran

2024Drug Metabolism and Disposition43 citationsDOIOpen Access PDF

Topics & Concepts

PeroxynitriteMitochondrial permeability transition poreMitochondrionAcetaminophenLiver injuryPharmacologyAutophagyMitophagyMedicineOxidative stressProgrammed cell deathChemistryBiochemistrySuperoxideEnzymeInternal medicineApoptosisDrug-Induced Hepatotoxicity and ProtectionLiver Disease and TransplantationLiver Disease Diagnosis and Treatment
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