Cardiac Amyloidosis
Michelle Bloom, Peter D. Gorevic
Abstract
Amyloidosis is a pathologic and clinical condition resulting from the accumulation of insoluble aggregates of misfolded proteins in tissues. Extracellular deposition of amyloid fibrils in the myocardium leads to cardiac amyloidosis, which is often overlooked as a cause of diastolic heart failure. Although cardiac amyloidosis was previously believed to have a poor prognosis, recent advances in diagnosis and treatment have emphasized the importance of early recognition and changed management of this condition. This article provides an overview of cardiac amyloidosis and summarizes current screening, diagnosis, evaluation, and treatment options.
Topics & Concepts
MedicineCardiac amyloidosisAmyloidosisAmyloid (mycology)Amyloid fibrilHeart failureAL amyloidosisClinical PracticePathologyIntensive care medicineDiseaseCardiologyImmunologyAmyloid βPhysical therapyImmunoglobulin light chainAntibodyAmyloidosis: Diagnosis, Treatment, OutcomesParathyroid Disorders and TreatmentsPeptidase Inhibition and Analysis