Olaparib and durvalumab in patients with germline BRCA-mutated metastatic breast cancer (MEDIOLA): an open-label, multicentre, phase 1/2, basket study
Susan M. Domchek, Sophie Postel‐Vinay, Seock‐Ah Im, Yeon Hee Park, Jean‐Pierre Delord, Antoîne Italiano, Jérôme Alexandre, Benoît You, Sara Bastian, Matthew Krebs, Ding Wang, Saiama N. Waqar, Mark C. Lanasa, Joon Haeng Rhee, Haiyan Gao, Vidalba Rocher-Ros, Emma V. Jones, Sakshi Gulati, Anna Coenen-Stass, Iwanka Kozarewa, Zhongwu Lai, Helen K. Angell, Laura Opincar, Pia Herbolsheimer, Bella Kaufman
Topics & Concepts
OlaparibMedicineMetastatic breast cancerBreast cancerOncologyPARP inhibitorTolerabilityInternal medicineBRCA mutationCancerDurvalumabAdverse effectImmunotherapyNivolumabBiologyBiochemistryPoly ADP ribose polymeraseGenePolymerasePARP inhibition in cancer therapyBRCA gene mutations in cancerAdvanced Breast Cancer Therapies