Nanoenzyme engineered neutrophil-derived exosomes attenuate joint injury in advanced rheumatoid arthritis via regulating inflammatory environment
Lei Zhang, Ziguo Qin, Han Sun, Xiang Chen, Jian Dong, Siyu Shen, Liming Zheng, Ning Gu, Qing Jiang
Abstract
with high sensitivity and specificity. Particularly, uPB-Exo induced a cascade of anti-inflammatory events via Th17/Treg cell balance regulation, thereby significantly ameliorating joint damage. Therefore, nanoenzyme functionalized exosomes hold the great potential for enhanced treatment of RA in clinic.
Topics & Concepts
SynovitisInflammationRheumatoid arthritisArthritisImmunologyProinflammatory cytokineMedicineChemistryExtracellular vesicles in diseaseAutoimmune and Inflammatory Disorders ResearchInflammasome and immune disorders