Evidence That Pathogenic Transglutaminase 2 in Celiac Disease Derives From Enterocytes
Rasmus Iversen, Sunniva F. Amundsen, Liv Kleppa, M. Fleur du Pré, Jorunn Stamnæs, Ludvig M. Sollid
Abstract
The enzyme transglutaminase 2 (TG2) plays a key role in celiac disease (CeD) pathogenesis through generation of immunogenic, deamidated gluten T-cell epitopes, and as a target of autoantibodies. The disorder is caused by a maladaptive immune response to cereal gluten proteins, and accumulating evidence suggest that interactions between gluten-specific T cells and TG2-specific B cells are important for driving the disease. A big remaining question is where in the body TG2, which is a cytosolic protein, encounters gluten and engages the immune system.
Topics & Concepts
Tissue transglutaminaseGlutenImmune systemPathogenesisDiseaseAutoantibodyImmunologyBiologyEpitopeAntigenEnzymeAntibodyMedicineBiochemistryPathologyCeliac Disease Research and ManagementPancreatitis Pathology and TreatmentAnimal health and immunology