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Synthesis of novel halogenated triarylpyrazoles as selective COX-2 inhibitors: Anti-inflammatory activity, histopatholgical profile and in-silico studies

Khaled R.A. Abdellatif, Eman K. A. Abdelall, Madlen B. Labib, Wael A. A. Fadaly, Taha H. Zidan

2020Bioorganic Chemistry34 citationsDOI

Topics & Concepts

CelecoxibChemistryADMEIn silicoPharmacologyIn vivoIC50EdemaIn vitroAnti-inflammatoryDocking (animal)BiochemistryMedicineInternal medicineBiologyNursingGeneBiotechnologySynthesis and biological activityInflammatory mediators and NSAID effectsSynthesis of heterocyclic compounds
Synthesis of novel halogenated triarylpyrazoles as selective COX-2 inhibitors: Anti-inflammatory activity, histopatholgical profile and in-silico studies | Litcius