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Bioisosteric replacements of the indole moiety for the development of a potent and selective PI3Kδ inhibitor: Design, synthesis and biological evaluation

Chengbin Yang, Chenyue Xu, Zhipeng Li, Yi Chen, Tianze Wu, Hui Hong, Mingzhu Lu, Jia Yu, Yongtai Yang, Xiaofeng Liu, Mingli Deng, Zhenxia Chen, Qingquan Li, Yun Ling, Yaming Zhou

2021European Journal of Medicinal Chemistry21 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryIdelalisibMyeloid leukemiaPI3K/AKT/mTOR pathwayIndole testPharmacologyPotencyMoietyIn vivoCell growthIC50In vitroLeukemiaCancer researchStereochemistryBiochemistrySignal transductionBiologyMedicineInternal medicineIbrutinibBiotechnologyChronic lymphocytic leukemiaPI3K/AKT/mTOR signaling in cancerCytokine Signaling Pathways and InteractionsChronic Lymphocytic Leukemia Research
Bioisosteric replacements of the indole moiety for the development of a potent and selective PI3Kδ inhibitor: Design, synthesis and biological evaluation | Litcius