Litcius/Paper detail

Structural and molecular basis for the substrate positioning mechanism of a new PL7 subfamily alginate lyase from the arctic

Fei Xu, Xiu‐Lan Chen, Xiaohui Sun, Fang Dong, Chunyang Li, Ping‐Yi Li, Haitao Ding, Yin Chen, Yu‐Zhong Zhang, Peng Wang

2020Journal of Biological Chemistry69 citationsDOIOpen Access PDF

Abstract

mediate the catalytic reaction. Our study uncovers, for the first time, the amino acid residues for alginate positioning in an alginate lyase and demonstrates that such residues involved in alginate positioning are conserved in other alginate lyases. This study provides a better understanding of the mechanisms of alginate degradation by alginate lyases.

Topics & Concepts

SubfamilyLyaseDimerSubstrate (aquarium)EnzymeChemistryStereochemistryBiochemistryBiologyGeneOrganic chemistryEcologySeaweed-derived Bioactive CompoundsMarine and coastal plant biologyPolyamine Metabolism and Applications