The Display between HPV Infection and Host Immunity in Cervical Cancer
Yuanyuan Gu, Tingting Li, Menglei Zhang, Junhao Chen, Fang Shen, Jingxin Ding, Guannan Zhou, Keqin Hua
Abstract
Most cervical cancers are related to the persistent infections of high-risk Human Papillomavirus (HPV) infections. Increasing evidence has witnessed the immunosuppressive effectiveness of HPV in the oncogenesis steps and progression steps. Here we review the immune response in HPV-related cervical malignancies and discuss the crosstalk between HPVs and the host immune response. Furthermore, we describe the identification and development of current immunotherapies in cervical cancer. Above all, we hope to provide a novel insight of the display between HPV infections and the host immune system.
Topics & Concepts
Immune systemCervical cancerCrosstalkImmunologyHPV infectionImmunityCarcinogenesisHuman papillomavirusMedicineCancerHost factorsHost responseVirologyBiologyVirusInternal medicineOpticsPhysicsCervical Cancer and HPV ResearchEndometrial and Cervical Cancer TreatmentsGenital Health and Disease