Ynones in Reflex‐Michael Addition, CuAAC, and Cycloaddition, as Well as their Use as Nucleophilic Enols, Electrophilic Ketones, and Allenic Precursors
Zhan‐Yong Wang, Kai‐Kai Wang, Rongxiang Chen, Huan Liu, Kaijun Chen
Abstract
The great success of ynones in synthesis is rooted in their multiple functional groups. Herein, reactions triggered by the reflex‐Michael addition, ynones in copper(I)‐catalyzed alkyne–azide cycloaddition (CuAAC), and formal cycloaddition as well as the use of ynones as nucleophilic enols, electrophilic ketones, and allenic precursors were thoroughly discussed and summarized. Multi‐component reactions, rearrangements, cycloadditions, regio‐ and stereoselective synthesis, coupling, and cycloaddition are depicted in detail. This review focused on advances of ynones chemistry in the last decade (2009–2019). We hope it will promote future research in this area.
Topics & Concepts
CycloadditionChemistryNucleophileElectrophileAzideStereoselectivityAlkyneNucleophilic additionOrganic chemistryCombinatorial chemistryCatalysisCatalytic Alkyne ReactionsCatalytic C–H Functionalization MethodsCyclopropane Reaction Mechanisms