<i>Flos magnoliae</i> constituent fargesin has an anti-allergic effect <i>via</i> ORAI1 channel inhibition
Hong Thi Lam Phan, Hyun Jong Kim, Woo Kyung Kim, Joo‐Hyun Nam
Abstract
= 12.46 ± 1.300 µM) but also on T-cell proliferation (by 87.74% ± 1.835%) and mast cell degranulation (by 20.11% ± 5.366%) at 100 µM. Our findings suggest that fargesin can be a promising candidate for the development of therapeutic drugs to treat allergic diseases.
Topics & Concepts
FlosORAI1Traditional medicineMedicinePharmacologyChemistryInternal medicineBiochemistrySTIM1CalciumAntioxidantRutinMagnolia and Illicium researchPlant-derived Lignans Synthesis and BioactivityPhytochemical compounds biological activities