Uptake of high-density lipoprotein by scavenger receptor class B type 1 is associated with prostate cancer proliferation and tumor progression in mice
C. Alicia Traughber, Emmanuel Opoku, Gregory Brubaker, Jennifer Major, Hanxu Lu, Shuhui Wang Lorkowski, Chase Neumann, Aimalie Hardaway, Yoon‐Mi Chung, Kailash Gulshan, Nima Sharifi, J. Mark Brown, Jonathan D. Smith
Abstract
cells in the same host model. Increased tumor volume was overall associated with reduced survival. We conclude that knocking out SR-B1 in prostate cancer tumors reduces HDL-associated increases in prostate cancer cell proliferation and disease progression.
Topics & Concepts
Scavenger receptorProstate cancerCancer researchScavengerCancerLipoproteinInternal medicineTumor progressionEndocrinologyBiologyChemistryBiochemistryMedicineCholesterolRadicalCancer, Lipids, and MetabolismPeroxisome Proliferator-Activated ReceptorsLipoproteins and Cardiovascular Health