Chiral Selenide/Achiral Sulfonic Acid Cocatalyzed Atroposelective Sulfenylation of Biaryl Phenols via a Desymmetrization/Kinetic Resolution Sequence
Huiyun Luo, Zihao Li, Deng Zhu, Qin Yang, Ren‐Fei Cao, Tong‐Mei Ding, Zhi‐Min Chen
Abstract
Enantioselective synthesis of axially chiral sulfur-containing biaryl derivatives through the electrophilic sulfenylation of biaryl phenols has been achieved for the first time. This catalytic asymmetric system, which involves sequential desymmetrization and kinetic resolution, is enabled by a combination of a novel 3,3'-disubstituted BINOL-derived selenide catalyst and an achiral sulfonic acid. Control experiments and computational studies suggest that multiple noncovalent interactions between the cocatalysts and substrate, especially a network of hydrogen bond interactions, play a crucial role in determining the enantioselectivity and reactivity.
Topics & Concepts
ChemistryKinetic resolutionDesymmetrizationPhenolsOrganic chemistrySelenideStereochemistryCatalysisEnantioselective synthesisSeleniumAxial and Atropisomeric Chirality SynthesisMolecular spectroscopy and chiralitySulfur-Based Synthesis Techniques