MUC16 affects the biological functions of ovarian cancer cells and induces an antitumor immune response by activating dendritic cells
Yan Zhai, Qi Lu, Tong Lou, Guangming Cao, Shuzhen Wang, Zhenyu Zhang
Abstract
BACKGROUND: most common lethal gynecological malignancy with a 5-year survival rate of about 47% and a localized stage diagnosis of 15%, leading to about 125,000 global deaths each year. Therefore, it is urgent to explore novel and effective strategies for radical cure. METHODS: -pulsed DCs. RESULTS: T-cells detected by Flow cytometry. CONCLUSIONS: . Our study offers promising DC-based immunotherapy of considerable clinical value for patients with ovarian cancer.
Topics & Concepts
Cancer researchCD80Ovarian cancerPI3K/AKT/mTOR pathwayGene knockdownCD86Flow cytometryEpithelial–mesenchymal transitionSmall hairpin RNABiologyChemistryCytotoxic T cellT cellImmune systemCancerCell cultureImmunologyCell biologyCD40Signal transductionMetastasisIn vitroGeneticsBiochemistryImmunotherapy and Immune ResponsesImmune Cell Function and InteractionT-cell and B-cell Immunology