An MMP-2 sensitive and reduction-responsive prodrug amphiphile for actively targeted therapy of cancer by hierarchical cleavage
Xueni Zhang, Lihui Dai, Yumeng Ding, Qian Liu, Xiaoya Li, Mengting Liu, Meng Meng, Jie Pan, Rimo Xi, Yongmei Yin
Abstract
A hierarchically cleaved amphiphile, mPEG-pep-etcSS-CPT, was synthesized to pursue actively targeted cancer therapy through self-assembly. This micelle can respond to MMP-2 achieving dePEGylation and releasing RGD peptides to be internalized into targetable tumor cells. Inside the cell, free CPT could be released by reduction-response leading to cytotoxicity.
Topics & Concepts
ProdrugAmphiphileCleavage (geology)CytotoxicityMatrix metalloproteinaseMicelleChemistryCancer researchPeptideCancer cellTargeted therapyCancerCombinatorial chemistryBiophysicsPharmacologyBiochemistryMedicineMaterials scienceIn vitroInternal medicineBiologyCopolymerOrganic chemistryFracture (geology)Composite materialPolymerAqueous solutionSupramolecular Self-Assembly in MaterialsPeptidase Inhibition and AnalysisRNA Interference and Gene Delivery