Solid-phase synthesis of DNA-encoded libraries <i>via</i> an “aldehyde explosion” strategy
Nicholas G. Paciaroni, John M. Ndungu, Thomas Kodadek
Abstract
We report chemistry suitable for the solid-phase synthesis of DNA-encoded libraries with an unusually high level of structural diversity. The strategy involves "exploding" an immobilized aldehyde into a plethora of different functional groups under DNA-compatible conditions.
Topics & Concepts
AldehydeDNACombinatorial chemistryChemistryDNA synthesisSolid-phase synthesisBiochemistryCatalysisPeptideChemical Synthesis and AnalysisMonoclonal and Polyclonal Antibodies ResearchCarbohydrate Chemistry and Synthesis