Inhibitory effect of Citrus flavonoids on the in vitro transport activity of human urate transporter 1 (URAT1/SLC22A12), a renal re-absorber of urate
Yu Toyoda, Tappei Takada, Hiroki Saito, Hiroshi Hirata, Ami Ota-Kontani, Naoyuki Kobayashi, Youichi Tsuchiya, Hiroshi Suzuki
Abstract
Abstract As hyperuricemia is a cause of urate-related diseases such as gout, the anti-hyperuricemic and/or uricosuric activity of food ingredients is receiving increased attention. Here, we examined the inhibitory activities of seven Citrus flavonoids against URAT1, a renal transporter involved in urate re-uptake from urine. We found that naringenin and nobiletin strongly inhibited URAT1, and may therefore serve as an anti-hyperuricemic food ingredient that can reduce the risk of urate-related diseases.
Topics & Concepts
HyperuricemiaNaringeninGoutChemistryUric acidTransporterInhibitory postsynaptic potentialPharmacologyBiochemistryMedicineFlavonoidInternal medicineGeneAntioxidantGout, Hyperuricemia, Uric AcidPharmacological Effects of Natural CompoundsMedicinal plant effects and applications