Herpes Simplex Virus Type 1 Infection Disturbs the Mitochondrial Network, Leading to Type I Interferon Production through the RNA Polymerase III/RIG-I Pathway
Noémie Berry, Rodolphe Suspène, Vincent Caval, Pierre Khalfi, Guillaume Beauclair, Stéphane Rigaud, Hervé Blanc, Marco Vignuzzi, Simon Wain-Hobson, Jean-Pierre Vartanian
Abstract
, we demonstrated the implication of mtDNA in the production of interferon and APOBEC3A expression during viral infection. We have shown that HSV-1 induces mitochondrial network fragmentation in a human model and confirmed the implication of RNA polymerase III/RIG-I signaling in the capture of cytosolic mtDNA.
Topics & Concepts
Mitochondrial DNAInterferonBiologyPolymeraseMolecular biologyMitochondrionHerpes simplex virusVirologyRNADNAHuman mitochondrial geneticsGeneCytosolVirusViral replicationCell biologyMT-RNR1RNA-dependent RNA polymeraseDNA polymeraseInnate immune systemRNA virusFragmentation (computing)DNA fragmentationDNA virusMitochondrial matrixEthidium bromideCell cultureRNA polymeraseNucleic acidHerpesvirus Infections and Treatmentsinterferon and immune responsesPoxvirus research and outbreaks