Structural Basis of PER-1-Mediated Cefiderocol Resistance and Synergistic Inhibition of PER-1 by Cefiderocol in Combination with Avibactam or Durlobactam in Acinetobacter baumannii
Xiaochen Liu, Tailong Lei, Yunxing Yang, Linghong Zhang, Haiyang Liu, Sebastián Leptihn, Yunsong Yu, Xiaoting Hua
Abstract
Cefiderocol is a novel siderophore cephalosporin that displays activity against Gram-negative bacteria. To establish cefiderocol susceptibility levels of Acinetobacter baumannii strains from China, we performed susceptibility testing and genomic analyses on 131 clinical isolates.
Topics & Concepts
Acinetobacter baumanniiBiologyAcinetobacterMicrobiologyCephalosporinPseudomonas aeruginosaBacteriaAntibioticsGeneticsAntibiotic Resistance in BacteriaPhenothiazines and Benzothiazines Synthesis and ActivitiesAntibiotic Use and Resistance