Synthesis of a novel diaquabis(1,10-phenanthroline)copper(II)chloride complex and its voltammetric application for detection of amoxicillin in pharmaceutical and biological samples
Ameha Debalke, Adane Kassa, Tihitinna Asmellash, Yonas Beyene, Meareg Amare, Getinet Tamiru Tigineh, Atakilt Abebe
Abstract
CuC)/GCE showed linear dependence on concentration of amoxicillin (2.0-100.0 μM) with LoD 0.0115 μM. While no amoxicillin was detected in the human blood serum sample, an amount 89.40-100.55% of the nominal level was detected in the analyzed eight tablet brands. Spike recovery in tablet samples (98.90-101.95%) and blood serum sample (102.20-101.37%); interference with an error (%RSD) of 0.00-4.51% in tablet and 0.00-2.10% in serum samples; excellent stability and reproducible results, added with the wide dynamic range and low LoD validated the method for amoxicillin determination in pharmaceutical formulations and human urine samples.