Modeling Neurodegenerative Disorders in Drosophila melanogaster
Harris Bolus, Kassi L. Crocker, Grace Boekhoff‐Falk, Stanislava Chtarbanova
Abstract
Drosophila melanogaster provides a powerful genetic model system in which to investigate the molecular mechanisms underlying neurodegenerative diseases. In this review, we discuss recent progress in Drosophila modeling Alzheimer’s Disease, Parkinson’s Disease, Amyotrophic Lateral Sclerosis (ALS), Huntington’s Disease, Ataxia Telangiectasia, and neurodegeneration related to mitochondrial dysfunction or traumatic brain injury. We close by discussing recent progress using Drosophila models of neural regeneration and how these are likely to provide critical insights into future treatments for neurodegenerative disorders.
Topics & Concepts
Amyotrophic lateral sclerosisNeurodegenerationDrosophila melanogasterNeuroscienceHuntington's diseaseDiseaseDrosophila (subgenus)BiologyAtaxiaMedicineGeneticsPathologyGeneGenetic Neurodegenerative DiseasesMitochondrial Function and PathologyAmyotrophic Lateral Sclerosis Research