Integrative transcriptomic analysis of the amyotrophic lateral sclerosis spinal cord implicates glial activation and suggests new risk genes
Jack Humphrey, Sanan Venkatesh, Rahat Hasan, Jake T. Herb, Kátia de Paiva Lopes, Fahri Küçükali, Marta Byrska-Bishop, Uday S. Evani, Giuseppe Narzisi, Delphine Fagegaltier, Kristel Sleegers, Hemali Phatnani, David A. Knowles, Pietro Fratta, Towfique Raj
Topics & Concepts
Amyotrophic lateral sclerosisBiologyC9orf72Spinal cordNeuroscienceTranscriptomeMicrogliaGene expressionAlternative splicingLumbar Spinal CordRNA splicingAstrocyteOligodendrocyteGeneGeneticsDiseaseCentral nervous systemTrinucleotide repeat expansionMedicinePathologyMyelinRNAAlleleImmunologyMessenger RNAInflammationAmyotrophic Lateral Sclerosis ResearchNeurogenetic and Muscular Disorders ResearchNeurological diseases and metabolism