CRISPR/Cas9 targeting liposomes knocked down multidrug resistance proteins in brain endothelial cells as a model to predict potential pharmacoresistance
Tianzhi Yang, Skye Curtis, Albert Bai, Abby Young, Derek Derosier, Shannon Ripley, Shuhua Bai
Topics & Concepts
TransfectionCRISPRLiposomeRhodamine 123EffluxMultiple drug resistanceChemistryP-glycoproteinCationic liposomeDoxorubicinCell biologyBiologyMolecular biologyBiochemistryGeneAntibioticsGeneticsChemotherapyAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene DeliveryDrug Transport and Resistance Mechanisms