Ex vivo cultivated oral mucosal epithelial cell transplantation for limbal stem cell deficiency: a review
João Victor Cabral, Catherine Joan Jackson, Tor Paaske Utheim, Kateřina Jirsová
Abstract
Destruction or dysfunction of limbal epithelial stem cells (LESCs) leads to unilateral or bilateral limbal stem cell deficiency (LSCD). Fifteen years have passed since the first transplantation of ex vivo cultivated oral mucosal epithelial cells (COMET) in humans in 2004, which represents the first use of a cultured non-limbal autologous cell type to treat bilateral LSCD. This review summarizes clinical outcomes from COMET studies published from 2004 to 2019 and reviews results with emphasis on the culture methods by which grafted cell sheets were prepared.
Topics & Concepts
Stem cellEx vivoTransplantationPathologyBiologyMedicineLimbal stem cellIn vivoImmunologyEpitheliumCell biologyCorneal epitheliumInternal medicineBiotechnologyCorneal Surgery and TreatmentsOcular Surface and Contact LensNasal Surgery and Airway Studies