Skeletal muscle-derived FSTL1 starting up angiogenesis by regulating endothelial junction via activating Src pathway can be upregulated by hydrogen sulfide
Mengyao Li, Rupan Gao, Qi Zhu, Ying Chen, Bei‐Bei Tao, Yi‐Chun Zhu
Abstract
The myocyte-derived paracrine protein FSTL1 acts on vascular endothelial cells and initiates the process of angiogenesis by opening the intercellular junction via activating Src kinase. H 2 S can significantly upregulate FSTL1 protein levels in skeletal muscles by increasing HuR expression.
Topics & Concepts
AngiogenesisCell biologyProto-oncogene tyrosine-protein kinase SrcParacrine signallingDownregulation and upregulationNeovascularizationUmbilical veinChemistryBiologyPhosphorylationCancer researchBiochemistryReceptorIn vitroGeneCancer, Hypoxia, and MetabolismAdipose Tissue and MetabolismMuscle metabolism and nutrition