Arene diversification through distal C(sp <sup>2</sup> )−H functionalization
Uttam Dutta, Sudip Maiti, Trisha Bhattacharya, Debabrata Maiti
Abstract
-) C-H activation remains more challenging due to the inaccessibility of these sites in the formation of energetically favorable organometallic pretransition states. Directing the catalyst toward the distal C-H bonds requires judicious template engineering and catalyst design, as well as prudent choice of ligands. This review aims to summarize the recent elegant discoveries exploiting directing group assistance, transient mediators or traceless directors, noncovalent interactions, and catalyst and/or ligand selection to control distal C-H activation.
Topics & Concepts
CatalysisSurface modificationChemistryArylCombinatorial chemistryLigand (biochemistry)Transition metalStereochemistryNanotechnologyMaterials scienceOrganic chemistryAlkylPhysical chemistryReceptorBiochemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsCatalytic Cross-Coupling Reactions