Anti-cancer and immunomodulatory evaluation of new nicotinamide derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: <i>in vitro</i> and <i>in silico</i> studies
Reda G. Yousef, Alaa Elwan, Ibraheem M. M. Gobaara, Ahmed B. M. Mehany, Wagdy M. Eldehna, Souad A. El‐Metwally, Bshra A. Alsfouk, Eslam B. Elkaeed, Ahmed M. Metwaly, Ibrahim H. Eissa
Abstract
docking, molecular dynamics simulations, ADMET, and toxicity studies were carried out.
Topics & Concepts
IC50ChemistrySorafenibIn silicoNicotinamideApoptosisPharmacologyIn vitroCell cycleCytotoxicityCytotoxic T cellDocking (animal)StereochemistryBiochemistryEnzymeCancer researchBiologyMedicineGeneHepatocellular carcinomaNursingCAR-T cell therapy researchAngiogenesis and VEGF in CancerHER2/EGFR in Cancer Research