Spontaneous Selection of <i>Cryptosporidium</i> Drug Resistance in a Calf Model of Infection
Muhammad M. Hasan, Erin E. Stebbins, Robert K. M. Choy, J. Robert Gillespie, Eugenio L. de Hostos, Peter G. Miller, Aisha Mushtaq, Ranae M. Ranade, José E. Teixeira, Christophe L. M. J. Verlinde, Adam Sateriale, Zhongsheng Zhang, Damon M. Osbourn, David W. Griggs, Erkang Fan, Frederick S. Buckner, Christopher D. Huston
Abstract
The intestinal protozoan Cryptosporidium is a leading cause of diarrheal disease and mortality in young children. There is currently no fully effective treatment for cryptosporidiosis, which has stimulated interest in anticryptosporidial development over the last ∼10 years, with numerous lead compounds identified, including several tRNA synthetase inhibitors.
Topics & Concepts
CryptosporidiumDrug resistanceSelection (genetic algorithm)DrugMicrobiologyBiologyVirologyPharmacologyFecesComputer scienceArtificial intelligenceParasitic Infections and DiagnosticsClostridium difficile and Clostridium perfringens researchViral gastroenteritis research and epidemiology