Delayed Hematologic Toxicities Following Axicabtagene Ciloleucel and Tisagenlecleucel CAR-T Cell Therapy: A Retrospective Analysis of Lymphocytopenia, Neutropenia, and Thrombocytopenia
Carina Bona, Roberto Lozano
Abstract
This study provides a 2024 update on survival outcomes and the frequency of hematologic complications, specifically lymphocytopenia, neutropenia, and thrombocytopenia, in patients treated with axicabtagene ciloleucel (axi-cel) and tisagenlecleucel (tisa-cel) CAR-T cell therapies. The study examined 56 patients diagnosed with diffuse large B-cell lymphoma who underwent CAR-T cell therapy from 2019 to March 2024. Among them, 34 patients received axi-cel (group A), and 22 patients were treated with
Topics & Concepts
MedicineNeutropeniaLymphocytopeniaLeukopeniaImmunologyInternal medicineToxicityLymphocyteCAR-T cell therapy researchVirus-based gene therapy researchBiomedical Ethics and Regulation