Litcius/Paper detail

FOXO: a key target in regulating aging and age-related diseases

Wei Wang, Hao Zhu, Qiaohui Jiang, Yiling Shi, Xiaobo Wang

2026Biogerontology8 citationsDOI

Topics & Concepts

AutophagyTranscription factorCell biologyBiologyKEAP1EpigeneticsSignal transductionOxidative stressmicroRNAPhenotypePhosphorylationOxidative phosphorylationForkhead Transcription FactorsRegulation of gene expressionCell signalingMechanism (biology)DephosphorylationFOXO1Reactive oxygen speciesSenescencePIN1Cellular stress responseFOXO3MediatorPI3K/AKT/mTOR pathwayMechanistic target of rapamycinProgrammed cell deathEpigenomeCREBGene expressionNutrient sensingMetabolic pathwayTranscriptional regulationFOXO transcription factor regulationGenetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence