NETosis Impact on Tumor Biology, Radiation, and Systemic Therapy Resistance
Yvonne M. Mowery, Jason J. Luke
Abstract
Neutrophil extracellular trap (NET)osis via lytic neutrophil death or neutrophil activation is associated with standard cancer therapies, notably including radiotherapy; is immunosuppressive; and may enhance metastasis and treatment resistance. This emerging area of research should be prioritized in drug development and standard of care treatment paradigms including radiation therapy, chemotherapy, and immunotherapy. See related article by Teijeira et al., p. 4131.
Topics & Concepts
Systemic therapyResistance (ecology)Radiation therapyBiologyMedicineCancer researchCancerImmunologyInternal medicineEcologyBreast cancerNeutrophil, Myeloperoxidase and Oxidative MechanismsNitric Oxide and Endothelin EffectsAntifungal resistance and susceptibility