A phosphatase-like nanomaterial promotes autophagy and reprograms macrophages for cancer immunotherapy
Didar Baimanov, Su Li, Xuejiao J. Gao, Xuejiao J. Gao, Rui Cai, Ke Liu, Junjie Li, Yuchen Liu, Yalin Cong, Xiaoyu Wang, Fen Liu, Qi Li, Guofang Zhang, Hui Wei, Jian Wang, Chunying Chen, Xingfa Gao, Xingfa Gao, Yang Li, Liming Wang
Abstract
. Furthermore, pre-coating the surface of LNO with a myeloid cell membrane significantly enhanced antitumor immunity. Our findings demonstrate that phosphatase-like nanozyme LNO can specifically induce macrophage autophagy, which improves therapeutic efficacy and offers valuable strategies for cancer immunotherapy.
Topics & Concepts
AutophagyCancer immunotherapyIn vivoImmunotherapyMacrophagePhosphataseCell biologyCancer researchCancer therapyChemistryCancerBiologyImmune systemImmunologyIn vitroPhosphorylationBiochemistryBiotechnologyApoptosisGeneticsAdvanced Nanomaterials in CatalysisNanoplatforms for cancer theranosticsAutophagy in Disease and Therapy