Sex differences in stress‐induced hyperalgesia and its mechanisms
Qiang Gao, Mei‐Qi Liu, Jia‐Xin Li, Yi Wang, Ying Zhang, Hui Zhu
Abstract
Chronic stress induces a variety of physiological and/or psychological abnormalities, including hyperalgesia. Researchers have discovered sex differences in the prevalence of stress-induced hyperalgesia (SIH) in recent years. Sex differences may be one of the reasons for the heterogeneity of susceptibility to stress-related diseases. In this review, the potential mechanisms of sex differences in SIH are discussed, such as hypothalamus-pituitary-adrenal axis responses, regulation of sex hormones, and immune system responses.
Topics & Concepts
HyperalgesiaImmune systemHormoneHypothalamusNeuroscienceHypothalamic–pituitary–adrenal axisPsychological stressChronic stressPsychologyMedicineInternal medicineImmunologyClinical psychologyNociceptionReceptorStress Responses and CortisolHormonal Regulation and HypertensionPain Mechanisms and Treatments