Monoterpenoid indole alkaloid dimers from the Melodinus axillaris induce G2/M phase arrest and apoptosis via p38 MAPK activation in HCT116 cells
Kaicheng Du, Xingyao Li, Changwei Zheng, Lantao Lai, Mingyi Shen, Yumeng Wang, Dali Meng
Topics & Concepts
ApoptosisChemistryWestern blotp38 mitogen-activated protein kinasesCell cycle checkpointMAPK/ERK pathwayFlow cytometryCell cycleIndole alkaloidAlkaloidCell biologyStereochemistryMolecular biologySignal transductionBiochemistryBiologyGeneAlkaloids: synthesis and pharmacologyBerberine and alkaloids researchTraditional and Medicinal Uses of Annonaceae