Autonomous follicle quality control mechanisms: innate immune signaling capabilities of granulosa cells
Prianka H. Hashim, Madeline J Perry, Michele T. Pritchard, Jennifer L. Gerton, Francesca E. Duncan
Abstract
We synthesize current evidence that granulosa cells possess unique innate immune signaling capabilities. We suggest the novel concept that this serves as a quality control surveillance mechanism by integrating signals from the oocyte and ovarian microenvironment to prevent poor-quality follicles from producing gametes that contribute to the next generation.
Topics & Concepts
Innate immune systemOocyteOvarian follicleImmune systemCell biologyMechanism (biology)BiologyQuality (philosophy)Control (management)Signal transductionImmunologyOvaryComputer scienceEndocrinologyEmbryoArtificial intelligenceEpistemologyPhilosophyReproductive System and PregnancyReproductive Biology and Fertility