Mussel-inspired injectable chitosan hydrogel modified with catechol for cell adhesion and cartilage defect repair
Siqi Zhou, Zhongwu Bei, Jian Wei, Xinxin Yan, Haiyan Wen, Yiping Cao, Haohuan Li
Abstract
, through the evaluation of gross observation and histology, the BMSC-laden CS-C hydrogel showed better reconstruction of hyaline cartilage than the untreated group and CS-C hydrogel only. Therefore, CS-C hydrogel laden with BMSC might be a promising strategy for repairing cartilage defects.
Topics & Concepts
CartilageChondrogenesisBiocompatibilitySwellingHyaline cartilageBiomedical engineeringSelf-healing hydrogelsChitosanHorseradish peroxidaseIn vivoMaterials scienceMesenchymal stem cellTissue engineeringChemistryBiophysicsAnatomyArticular cartilagePolymer chemistryBiochemistryOsteoarthritisComposite materialPathologyOrganic chemistryMedicineBiotechnologyBiologyEnzymeAlternative medicineOsteoarthritis Treatment and MechanismsPeriodontal Regeneration and TreatmentsKnee injuries and reconstruction techniques