“Clicking“ fragment leads to novel dual-binding cholinesterase inhibitors
Zuzanna Molęda, Anna Zawadzka, Zbigniew Czarnocki, Leticia Monjas, Anna K. H. Hirsch, Armand Budzianowski, Jan K. Maurin
Topics & Concepts
ChemistryButyrylcholinesteraseCholinesteraseCycloadditionEnzymeStereochemistryAcetylcholinesteraseAzideClick chemistryBinding siteEnzyme inhibitorActive siteCombinatorial chemistryBiochemistryAchéPharmacologyCatalysisOrganic chemistryMedicineCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsEnzyme function and inhibition